Week 7 kicks off with Pittsburgh at Cincinnati on Thursday Night Football, followed by London’s Rams vs. Jaguars and the Colts at Chargers. Bills and Ravens are on bye. The odds table shows a mix of sizable favorites and close picks, including Steelers -5.5 at CIN, Rams -3.5 over JAX, and Chiefs as heavy favorites. Several matchups churn high-scoring potential while others hinge on defensive play and game script. Rosters should heed byes and travel effects as the slate unfolds.

Key Week 7 themes: spread-driven fantasy value in shootouts (TB vs DET, PHI vs MIN, ATL vs SF), streaming defenses in favorable matchups, and careful lineup construction around late-window games (IND-LAC, WSH-DAL). Monitor injury updates and weather, especially for London and prime time games, to capitalize on mismatches and avoid landmines.

Puka Nacua exited Sunday's win with an ankle sprain, but the Rams say it isn’t a long-term issue and he’ll be day-to-day. A clean scan supports a cautious, weekly return plan, with usage tailored to his movement and style. LA faces Week 7 in London against Jacksonville, adding a travel wrinkle to a wary schedule for fantasy managers.

Through five games, Nacua led the NFL in receptions and receiving yards, making his health a make-or-break factor for the Rams’ passing game. His status will drive lineup decisions and potential shifts behind him as the Rams balance risk and reward.